M1 Macrophages Increase Endothelial Permeability and Enhance p38 Phosphorylation via PPAR- γ/CXCL13-CXCR5 in Sepsis

Conclusion: M1 macrophages induced endothelial hyperpermeability and promoted p38 phosphorylation in sepsis by inhibiting PPAR- γ to increase CXCL13 production. PPAR-γ/CXCL13-CXCR5 signaling could be a promising novel therapeutic target for sepsis.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research