Y-Chromosome Gene, < em > Uty < /em > , Protects Against Pulmonary Hypertension by Reducing Proinflammatory Chemokines

CONCLUSIONS: Uty, is protective against PH. Reduction of Uty expression results in increased expression of proinflammatory chemokines CXCL9 and CXCL10 which trigger endothelial cell death and PH. Inhibition of Cxcl9 and Cxcl10 rescues PH development in multiple experimental models.PMID:35504005 | DOI:10.1164/rccm.202110-2309OC

Source: Am J Respir Crit Car... - May 3, 2022 Category: Intensive Care Authors: Christine M Cunningham Min Li Gregoire Ruffenach Mitali Doshi Laila Aryan Jason Hong John Park Haley Hrncir Lejla Medzikovic Soban Umar Arthur P Arnold Mansoureh Eghbali Source Type: research