Leptospiral major outer membrane protein: LipL32

Leptospirosis is now considered a re-emerging infectious disease and may become a severe threat to both developing and developed countries. Technological developments in the last 10 years identified several potential candidate proteins to play significant roles in pathogenesis. Many of these candidate proteins proved to be vital in disease diagnosis and treatment. The 32-kDa lipoprotein (LipL32) is the major surface protein present on pathogenic strains of Leptospira. The involvement of LipL32 in pathogenesis of Leptospirosis has been studied extensively and different lines of evidence indicate that LipL32 is a lipid-modified membrane protein that is similar to several other prokaryotic lipoproteins. This review focuses on LipL32 and its role as a therapeutic and diagnostic target.
Source: Reviews in Medical Microbiology - Category: Microbiology Tags: Pathogenicity Source Type: research