The efficacy and safety of insertable cardiac monitor on atrial fibrillation detection in patients with ischemic stroke: a systematic review and meta-analysis

AbstractAtrial fibrillation (AF) leads to a high risk of recurrent stroke, and the insertable cardiac monitor (ICM), as a new kind of electrocardiographic monitoring device, has been proven to enhance the recognition rate of AF. The aim of this systematic review was to evaluate the efficacy and safety of the ICM use in AF detection of patients with stroke. We pooled 1233 patients from three randomized controlled trials (RCTs). The detection rate of AF was superior in the ICM group to that in the control group at 6  months (risk ratio [RR], 4.63;P <  0.0001; 95% confidence interval [CI], 2.17–9.90) and 12 months (RR, 5.04;P <  0.00001; 95% CI, 2.93 to 8.68). Patients in the ICM group had a higher rate of oral anticoagulant usage (RR, 2.76;P <  0.00001; 95% CI, 1.89–4.02). However, there was no difference in the time to first detection of AF within 12 months (mean difference, − 8.28;P = 0.82; 95% CI, − 77.84–61.28) or the rate of recurrent ischemic stroke or transient ischemic attack (RR, 0.88;P = 0.51; 95% CI, 0.60–1.28) between the ICM and control groups. In addition, the ICM group experienced more adverse events than the control group within 12 months (RR, 4.42;P = 0.002; 95% CI, 1.69–11.55). To conclude, the sensitivity of ICM is superior to that of conventional external cardiac monitoring. Reducing adverse reactions will be a new development direction of ICM.
Source: Journal of Neurology - Category: Neurology Source Type: research