Orexin-a elevation in antipsychotic-treated compared to drug-free patients with schizophrenia: A medication effect independent of metabolic syndrome

CONCLUSION: With the inclusion of drug-free patients rather than healthy controls for comparison, we demonstrated that orexin-A is upregulated following APD treatment even after we controlled the potential effect from MS, suggesting an independent effect of APDs on orexin-A levels. Furthermore, the effect differed between APDs with dissimilar obesogenicity, i.e. less obesogenicity likely associated with higher orexin-A levels. Future prospective studies exploring the causal relationship between APDs treatment and orexin-A elevation as well as the underlying mechanisms are warranted.PMID:35396156 | DOI:10.1016/j.jfma.2022.03.008

Source: J Formos Med Assoc - April 9, 2022 Category: General Medicine Authors: Po-Yu Chen Chin-Kuo Chang Chun-Hsin Chen Su-Chen Fang Valeria Mondelli Chih-Chiang Chiu Mong-Liang Lu Ling-Ling Hwang Ming-Chyi Huang Source Type: research