TRAIL-sensitizing Cytochalasins from the Endophytic Fungus Phoma multirostrata

Planta Med DOI: 10.1055/a-1755-5411Seven undescribed cytochalasins, multirostratins K–Q (2–8), together with one known analogue, cytochalasin Z3 (1), were isolated from the culture of Phoma multirostrata XJ-2-1, an endophytic fungus obtained from the root of Parasenecio albus. Their structures with absolute configurations were determined by 1D and 2D NMR, high-resolution electrospray ionization mass spectrometry (HRESIMS), electronic circular dichroism (ECD), single-crystal X-ray crystallography, and chemical methods. The structure of ascochalasin was revised from Δ13 to Δ21 by detailed analysis of the NMR data and by comparison with the data for 7. In a TRAIL (tumor necrosis factor related apoptosis inducing ligand)-resistance-overcoming experiment, co-treatment of 2 or 6 with TRAIL reduced the cell viability of A549 cells by 30.3 % and 27.5 % at 10 µM, respectively. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract

Source: Planta Medica - January 31, 2022 Category: Drugs & Pharmacology Authors: Ruan, Hanli Peng, Xiaogang Ouyang, Qianxi Pei, Jiao Chang, Jinling Qin, Chunlun Tags: Original Papers Source Type: research