Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases [Biochemistry]

As natural chemokine inhibitors, evasin proteins produced in tick saliva are potential therapeutic agents for numerous inflammatory diseases. Engineering evasins to block the desired chemokines and avoid off-target side effects requires structural understanding of their target selectivity. Structures of the class A evasin EVA-P974 bound to human CC chemokine ligands...

Source: Proceedings of the National Academy of Sciences - February 25, 2022 Category: Science Authors: Ram Prasad Bhusal, Pramod Aryal, Shankar Raj Devkota, Rina Pokhrel, Menachem J. Gunzburg, Simon R. Foster, Herman D. Lim, Richard J. Payne, Matthew C. J. Wilce, Martin J. Stone Tags: Biochemistry Biological Sciences Source Type: research