Switchable assembly and function of antibody complexes in vivo using a small molecule [Biochemistry]

The antigen specificity and long serum half-life of monoclonal antibodies have made them a critical part of modern therapeutics. These properties have been coopted in a number of synthetic formats, such as antibody–drug conjugates, bispecific antibodies, or Fc-fusion proteins to generate novel biologic drug modalities. Historically, these new therapies have...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biochemistry Biological Sciences Source Type: research