Call for a universal PIMS-TS/MIS-C case definition

In April 2020, reports emerged of a new paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS). Numerous clinical uncertainties of PIMS-TS are still contested regularly in clinical practise today. These include distinguishing PIMS-TS from other common causes of childhood febrile illness and its pathogenesis. Disparity in clinical guidance exacerbates this uncertainty. This letter calls for a universal PIMS-TS case definition, which could improve coherency in clinical practise and research. The first case definition released by the Royal College of Paediatrics and Child Health in May 20201 is broad and takes a cautionary approach to SARS-CoV-2 testing. Case definitions from the WHO2 and the Centers for Disease Control and Prevention (CDC)3 quickly followed with one notable difference: requirement of evidence of SARS-CoV-2 infection or previous exposure (table 1). Further research is needed to compare the diagnostic accuracy of the three definitions,...
Source: Archives of Disease in Childhood - Category: Pediatrics Authors: Tags: COVID-19 PostScript Source Type: research