Nonenzymatic assembly of active chimeric ribozymes from aminoacylated RNA oligonucleotides [Biochemistry]

Aminoacylated transfer RNAs, which harbor a covalent linkage between amino acids and RNA, are a universally conserved feature of life. Because they are essential substrates for ribosomal translation, aminoacylated oligonucleotides must have been present in the RNA world prior to the evolution of the ribosome. One possibility we are exploring...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biochemistry Biological Sciences Source Type: research