Fungal gasdermin-like proteins are controlled by proteolytic cleavage [Genetics]

Gasdermins are a family of pore-forming proteins controlling an inflammatory cell death reaction in the mammalian immune system. The pore-forming ability of the gasdermin proteins is released by proteolytic cleavage with the removal of their inhibitory C-terminal domain. Recently, gasdermin-like proteins have been discovered in fungi and characterized as cell...

Source: Proceedings of the National Academy of Sciences - February 8, 2022 Category: Science Authors: Corinne Clave, Witold Dyrka, Elizabeth A. Turcotte, Alexandra Granger–Farbos, Lea Ibarlosa, Benoit Pinson, Russell E. Vance, Sven J. Saupe, Asen Daskalov Tags: Genetics Biological Sciences Source Type: research