Red Cell Distribution Width is independently associated with Mortality in Sepsis

Background: Mortality in sepsis remains high. Studies in small cohorts have shown that red cell distribution width (RDW) is associated with mortality. The aim of this study was to validate these findings in a large multi-centre cohort. Methods: We conducted this retrospective analysis of the multi-center eICU Collaborative Research Database in 16,423 septic patients. We split the cohort in patients with low (≤15%; n=7,129) and high (>15%; n=9,294) RDW. Univariable and multivariable multilevel logistic regression were used to fit regression models for the binary primary outcome of hospital mortality and the secondary outcome ICU mortality with hospital unit as random effect. Optimal cut-offs were calculated using the Youden-index. Results: Patients with high RDW were more often older than 65 years (57% vs. 50%; p
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research