IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment

IL-17A is critical for maintaining intestinal integrity and may play a beneficial role in IBD, but the extent of its tissue-specific roles remains unclear. Lin et  al. show that IL-17A acts specifically on Lgr5+ intestinal stem cells to induce Atoh1 expression and promote differentiation into secretory cells. Furthermore, IL-17A protects against DSS-induced injury through ATOH1+ cell-mediated regeneration of Lgr5+ ISCs.

Source: Immunity - January 25, 2022 Category: Allergy & Immunology Authors: Xun Lin, Stephen J. Gaudino, Kyung Ku Jang, Tej Bahadur, Ankita Singh, Anirban Banerjee, Michael Beaupre, Timothy Chu, Hoi Tong Wong, Chang-Kyung Kim, Cody Kempen, Jordan Axelrad, Huakang Huang, Saba Khalid, Vyom Shah, Onur Eskiocak, Olivia B. Parks, Arta Tags: Article Source Type: research