Crystal structure of betaine aldehyde dehydrogenase from Burkholderia pseudomallei

This study reports apo and cofactor-bound crystal structures of the potential drug target betaine aldehyde dehydrogenase (BADH) from B.   pseudomallei. A structural comparison identified similarities to BADH from Pseudomonas aeruginosa which is inhibited by the drug disulfiram. This preliminary analysis could facilitate drug-repurposing studies for B. pseudomallei.

Source: Acta Crystallographica Section F - January 27, 2022 Category: Biochemistry Authors: Beard, D.K. Subramanian, S. Abendroth, J. Dranow, D.M. Edwards, T.E. Myler, P.J. Asojo, O.A. Tags: Burkholderia pseudomallei melioidosis disulfiram betaine aldehyde dehydrogenase inhibition drug repurposing research communications Source Type: research