Effects of Sildenafil, a Phosphodiesterase Type 5 Inhibitor, on the Primary Single Afferent Activity of the Rat Bladder

ConclusionsThese results indicate that sildenafil can inhibit Aδ‐fibers (partly also C‐fibers) of the primary bladder mechanosensitive afferents of the rat although these effects may be partially influenced by systemic hypotension. The present results support the view that the NO/cGMP signaling pathway plays an inhibitory role in the bladder afferent transduction, and thus improves storage symptoms.

Source: LUTS: Lower Urinary Tract Symptoms - January 1, 2015 Category: Urology & Nephrology Authors: Naoki AIZAWA, Hiroki ITO, Rino SUGIYAMA, Tetsuya FUJIMURA, Hiroshi FUKUHARA, Haruki KUME, Yukio HOMMA, Yasuhiko IGAWA Tags: ORIGINAL ARTICLE Source Type: research