An immunohistochemical study of potential diagnostic and therapeutic biomarkers of wild‐type gastrointestinal stromal tumours

ConclusionsAll five antibodies failed, individually or collectively, to represent highly sensitive and highly specific markers for wild‐type GIST. However, whereas HER2 has been excluded as a therapeutic biomarker, both EGFR and IGF1R are expressed by some wild‐type GISTs and are therefore potential therapeutic targets.

Source: Histopathology - March 17, 2015 Category: Pathology Authors: Newton A C S Wong, Jenny Wingate, Elise Gradhand Tags: Original Article Source Type: research