Two new ɑ-pyrone derivatives from the endophytic Diaporthe sp. ECN371

AbstractDiaportholides A (1) and B (2), two polyketides with ɑ-pyrone moieties, were isolated from the cultures of an endophyticDiaporthe sp. ECN371 isolated fromOrixa japonica, together with four known polyketides, phomopsolide B (3), phomopsolidones A (4) and B (5), and 5-[(1R)-1-hydroxyethyl]- γ-oxo-2-furanbutanoic acid (6). The structures of1 and2 were determined by extensive analysis of NMR and MS spectroscopic data. Furthermore, the structure of2 was confirmed by analyzing the single-crystal X-ray diffraction data. The luciferase reporter gene assay revealed that among all isolated compounds (1 –6),3, a known ɑ-pyrone derivative, exhibited agonistic activity against the peroxisome proliferator-activated receptor ɑ, which is an important regulator of lipid metabolism in humans.Graphical abstract
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research