A synthetic resveratrol analog termed Q205 reactivates latent HIV-1 through activation of P-TEFb

This study provides a unique insight into resveratrol modified derivatives as promising leads for preclinical LRAs, which in turn may help toward inhibitor design and chemical optimization for improving HIV-1 shock-and kill-based efforts.PMID:34971588 | DOI:10.1016/j.bcp.2021.114901

Source: Biochemical Pharmacology - December 31, 2021 Category: Drugs & Pharmacology Authors: Taizhen Liang Ziyao Wu Yibin Li Chao Li Kangni Zhao Xinman Qiao Heng Duan Xuanxuan Zhang Shuwen Liu Baomin Xi Lin Li Source Type: research