Evaluation of diagnostic factors used to refer children with constipation for rectal biopsies

ConclusionIn children referred for rectal biopsy, the factors most indicative of Hirschsprung ’s disease were “male sex”, “failure to thrive”, “gross abdominal distention plus vomiting” and “fulfils the Rome 4 criteria for functional constipation”. Notably, the prevalence of Hirschsprung’s disease decreased with the increasing age of the children. Girls referred for a bio psy rarely had Hirschsprung’s disease, especially those older than 1 month.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research