Neonatal Congenital Pulmonary Airway Malformation Associated with Mucinous Adenocarcinoma and KRAS Mutations

Congenital cystic adenomatoid malformation (CCAM) is a parenchymal malformation of the lung characterized by cystic and solid change of variable size with a prevalence rate in Europe of 1.06/10,000 live births.[1] Stocker described 3 histological subtypes in 1977 [2], revising and expanding the classification to 5 subtypes in 2002 and re-aligning them as generic congenital pulmonary airway malformations (CPAMs).[3] At least in the UK, most lesions are identified on antenatal ultrasound screening, though postnatally they can present with respiratory distress, secondary infection and pneumothorax.
Source: Journal of Pediatric Surgery - Category: Surgery Authors: Source Type: research