CD99 in Malignant Hematopoiesis

CD99 was first discovered in 1979 as human thymus-leukemia antigen.1 CD99 is a highly O-glycosylated transmembrane protein encoded by the CD99 or previously known as MIC2 gene.2 CD99 is located in the pseudoautosomal region (PAR) of the Y (Yp11-Ypter) and X (Xp22.33-Xpter) chromosomes in humans.3,4 The CD99 gene encodes two distinct proteins: a wild-type full-length CD99 long isoform (CD99 L) with 185 amino acids (molecular weight of 32 kDa) and a truncated short isoform (CD99 S) with 161 amino acids as consequence of alternative splicing (28 kDa).
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research