New insights into β-cell failure, regeneration and replacement

Nature Reviews Endocrinology, Published online: 10 December 2021; doi:10.1038/s41574-021-00611-0In 2021, several discoveries shed light on the pathomechanisms of β-cell failure during the initiation and progression of diabetes mellitus, and validated novel molecular targets for intervention. Moreover, the field of stem-cell-derived replacements for β-cells is rapidly advancing. These advances bring us closer to therapies to protect and/or regenerate β-cell mass.
Source: Nature Reviews Endocrinology - Category: Endocrinology Authors: Source Type: research