Novel biomarker panel measuring endothelial injury identifies patients at risk of coronary artery syndrome and discordance with low-density lipoprotein cholesterol

Background

Individuals with no history of coronary artery disease can develop acute coronary syndrome (ACS), often in the absence of major risk factors including low-density lipoprotein cholesterol (LDL-C). We identified risk factors and biomarkers that can help identify those at discordantly high risk of ACS with normal LDL-C using a novel validated coronary artery disease predictive algorithm (CADPA) incorporating biomarkers of endothelial injury.

Methods

Five-year predicted ACS risk was calculated for 6392 persons using CADPA. Persons were classified as low (

Source: Coronary Artery Disease - December 9, 2021 Category: Cardiology Tags: Images in CAD Source Type: research