Cancers, Vol. 13, Pages 6021: EBV-Driven Lymphoproliferative Disorders and Lymphomas of the Gastrointestinal Tract: A Spectrum of Entities with a Common Denominator (Part 3)

Cancers, Vol. 13, Pages 6021: EBV-Driven Lymphoproliferative Disorders and Lymphomas of the Gastrointestinal Tract: A Spectrum of Entities with a Common Denominator (Part 3) Cancers doi: 10.3390/cancers13236021 Authors: Magda Zanelli Francesca Sanguedolce Andrea Palicelli Maurizio Zizzo Giovanni Martino Cecilia Caprera Valentina Fragliasso Alessandra Soriano Fabrizio Gozzi Luca Cimino Francesco Masia Marina Moretti Moira Foroni Loredana De Marco David Pellegrini Hendrik De Raeve Stefano Ricci Ione Tamagnini Alessandro Tafuni Alberto Cavazza Francesco Merli Stefano A. Pileri Stefano Ascani EBV is the first known oncogenic virus involved in the development of several tumors. The majority of the global population are infected with the virus early in life and the virus persists throughout life, in a latent stage, and usually within B lymphocytes. Despite the worldwide diffusion of EBV infection, EBV-associated diseases develop in only in a small subset of individuals often when conditions of immunosuppression disrupt the balance between the infection and host immune system. EBV-driven lymphoid proliferations are either of B-cell or T/NK-cell origin, and range from disorders with an indolent behavior to aggressive lymphomas. In this review, which is divided in three parts, we provide an update of EBV-associated lymphoid disorders developing in the gastrointestinal tract, often representing a challenging diagnostic and therapeutic...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research