Fc εRI Cluster Size Determines Effective Mast Cell Desensitization without Effector Responses in vitro

Conclusions: We demonstrate that the optimal size of IgE-Fc εRI clusters for in vitro BMMC desensitization differed significantly depending on allergenicity, and the efficacy of desensitization was reflected by IgE-FcεRI cluster formation. Our study provides information on the characteristics of IgE-FcεRI internalization for successful desensitization in vitro.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research