Delphinidin diminishes in vitro interferon- γ and interleukin-17 producing cells in patients with psoriatic disease

Immunol Res. 2021 Nov 25. doi: 10.1007/s12026-021-09251-y. Online ahead of print.ABSTRACTThe anthocyanidin delphinidin reduces psoriasiform lesions and inflammatory mediators in human cell culture systems. Its role in psoriatic disease has not yet been investigated. We assessed delphinidin's in vitro immunomodulatory effect on ex vivo stimulated peripheral blood mononuclear cells (PBMCs) from 50 individuals [26 with psoriasis, 10 with psoriatic arthritis (PsA) and 14 healthy controls (HCs)]. Cells were either left untreated or stimulated with PMA plus ionomycin in the presence or absence of delphinidin. Intracellular production of interferon-γ (IFNγ), interleukin-17A (IL-17A), and interleukin-10 (IL-10) was measured flow cytometrically. Delphinidin dose-dependently reduced IFNγ+ T cells from patients and HCs. The mean IFNγ decrease in CD4+ T subpopulations was 42.5 ± 28% for psoriasis patients, 51.8 ± 21.5% for PsA patients and 49 ± 17% for HCs (p
Source: Cell Research - Category: Cytology Authors: Source Type: research

Related Links:

Conclusions (i.e., comparable) are based on an overlap of pairwise 95 percent credible intervals.1c. PASI 90 is defined as at least 90 percent improvement from baseline in the PASI score. The PASI score grades the amount of surface area on each body region that is covered by PsO plaques and the severity of plaques for their redness, thickness, and scaliness.13 PASI 90 was not a controlled endpoint in DISCOVER-1 or -2.8,9d. TREMFYA q4w dosing is not currently FDA-approved.2e. The PsA-modified vdH-S score combines erosion and joint space narrowing scores derived from radiographs of joints in body regions impacted by PsA.14 T...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
New Brunswick, N.J. (January 25, 2022) – Johnson &Johnson (NYSE: JNJ) today announced results for fourth-quarter and full year 2021. “Our 2021 performance reflects continued strength across all segments of our business. Guided by Our Credo, I am honored to assume the role of CEO, leading our global teams in continuing our work to deliver life-changing solutions to consumers, patients, and health care providers” said Joaquin Duato, Chief Executive Officer. “Given our strong results, financial profile, and innovative pipeline we are well positioned for success in 2022 and beyond.” OVERALL FI...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Financial Source Type: news
The spondyloarthritides (SpA) are a group of overlapping chronic immune-mediated inflammatory diseases, the most common being psoriatic arthritis (PsA) and axial spondyloarthritis. Other, less common diseases within the SpA family include reactive arthritis, enteropathic arthritis and SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis). Shared features include a propensity to affect the peripheral and axial skeleton through enthesitis and synovitis, cutaneous and/or nail psoriasis, uveitis, inflammatory bowel disease, the absence of rheumatoid factor and an increased frequency of HLA-B27 variants.
Source: Medicine - Category: Internal Medicine Authors: Tags: Spondyloarthropathies Source Type: research
Exp Ther Med. 2022 Feb;23(2):152. doi: 10.3892/etm.2021.11075. Epub 2021 Dec 17.ABSTRACTLong considered a skin-limited condition, psoriasis is currently defined as a chronic, immune-mediated inflammatory disease, presenting, besides the skin changes, important systemic manifestations, the most common being: psoriatic arthritis, cardiovascular disease, metabolic syndrome, diabetes, inflammatory bowel disease and nonalcoholic steatohepatitis. It is a disease with a strong psycho-emotional and social impact, both through skin changes such as pruritic, scaly erythematous plaques, and through the association of comorbidities th...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Authors: Source Type: research
We present the case of a 49-year-old female patient with diabetes and psoriasis and psoriatic arthritis treated with an adalimumab biosimilar who developed a severe PAE of the palmoplantar pustular type. Treatment with adalimumab was stopped and the patient switched to ixekizumab which was successful. When a paradoxical r eaction develops during biologic therapy, especially when it is severe as in our patient, switching to another class of biologics is advised.
Source: Dermatology and Therapy - Category: Dermatology Source Type: research
The approval is the second indication for the anti-interleukin 23 monoclonal antibody after approval for plaque psoriasis was granted in 2019.News Alerts
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Rheumatology News Alert Source Type: news
We report here on patients with IBD.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Uncontrolled Therapeutic Observations in Humans Using Biologic or Non-Biologic Agents Source Type: research
It remains unclear whether patients with COVID-19 and those who receive biologic therapy for psoriasis or psoriatic arthritis have an increased risk of infection or of a worse outcome. Piaserico et  al. performed an analysis of the quality and potential limitations of 25 published studies on the risk and outcomes of COVID-19 in this patient population. A high risk of bias was identified in all the publications, and none of the studies reached a score of ≥75% on the Newcastle-Ottawa Scale, w hich measures study quality.
Source: Journal of Investigative Dermatology - Category: Dermatology Tags: Clinical Snippets Source Type: research
CONCLUSION: Excessive Matrix metalloproteinases activity is associated with articular destruction. Their levels can reflect disease activity, structural damage, and response to TNFi in patients with spondyloarthritis. Nevertheless, further studies are needed to confirm these results.PMID:35049445 | DOI:10.2174/2772432817666220113112809
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Source Type: research
CONCLUSIONS: Unsupervised clustering analysis revealed differences in circulating memory Th cells between psoriasis and PsA patients compared to HC; however, no specific subset was identified characterizing subclinical PsA patients.PMID:35045868 | DOI:10.1186/s13075-021-02714-5
Source: Cell Research - Category: Cytology Authors: Source Type: research
More News: Arthritis | Cytology | Psoriasis | Psoriatic Arthritis | Rheumatology