Assessment of Tissue Perfusion Using the Peripheral Perfusion Index and Lactate Clearance in Shock in Pediatric Patients

Conclusion: Perfusion index (PI), lactate, and lactate clearance provided comparable sensitivity and specificity for predicting outcomes among pediatric patients with shock Therefore, we suggest that the PI is an inexpensive, rapid, and non-invasive tool that can be used to predict illness severity and mortality in busy pediatric intensive care units and emergency departments. This tool may guide better patient triage and an earlier diagnosis of shock in this setting.
Source: Shock - Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research

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In conclusion, fibroblasts in monolayers cultured with soluble pentosidine and tridimensional in vitro skin constructs exposed to the combination of AGEs and UVA promote an inflammatory state and an alteration of the dermal compartment in relation to an elastosis-like environment.
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Rev Endocr Metab Disord. 2022 Jan 15. doi: 10.1007/s11154-021-09708-3. Online ahead of print.ABSTRACTIt is well-established that adipose tissue accumulation is associated with insulin resistance through multiple mechanisms. One major metabolic link is the classical Randle cycle: enhanced release of free fatty acids (FFA) from hydrolysis of adipose tissue triglycerides impedes insulin-mediated glucose uptake in muscle tissues. Less well studied are the different routes of this communication. First, white adipose tissue depots may be regionally distant from muscle (i.e., gluteal fat and diaphragm muscle) or contiguous to mus...
Source: ENDOCR REV - Category: Endocrinology Authors: Source Type: research
In conclusion, this technology can be used to fabricate functional tissues and organs for regenerative therapies and in vitro experimental models.PMID:35032535 | DOI:10.1016/j.mvr.2022.104321
Source: Cell Research - Category: Cytology Authors: Source Type: research
AbstractNuclear medicine neuroimaging is able to show functional and molecular biologic abnormalities in various neuropsychiatric diseases. Therefore, it has played important roles in the clinical diagnosis and in research on the normal and pathological states of the brain. More than 400 outstanding studies have been conducted by Korean researchers over the past 60  years. In the 1990s, when multiheaded single-photon emission computed tomography (SPECT) scanners were first introduced in South Korea, stroke research using brain perfusion SPECT was conducted. With the spread of positron emission tomography (PET) scanner...
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
In this study we evaluated the predictive value of CEUS in patients treated with CLS for end-stage atherosclerotic occlusive disease of the lower extremity (ASO-LE).MethodsThis was a prospective study that included patients with end-stage ASO-LE and moderate to severe pain who had undergone a CEUS examination and CLS procedure and who were observed for 12  months after surgery. The patients’ characteristics and prognostic factors, including lower limb pain score, skin temperature, walking distance, and ulcer and gangrene healing, were recorded.ResultsFifty-eight patients with a mean age of 66.24 (range 58 &ndash...
Source: Pain and Therapy - Category: Anesthesiology Source Type: research
AbstractIt is well-established that adipose tissue accumulation is associated with insulin resistance through multiple mechanisms. One major metabolic link is the classical Randle cycle: enhanced release of free fatty acids (FFA) from hydrolysis of adipose tissue triglycerides impedes insulin-mediated glucose uptake in muscle tissues. Less well studied are the different routes of this communication. First, white adipose tissue depots may be regionally distant from muscle (i.e., gluteal fat and diaphragm muscle) or contiguous to muscle but separated by a fascia (Scarpa ’sfascia in the abdomen,fascia lata in the thigh)...
Source: Reviews in Endocrine and Metabolic Disorders - Category: Endocrinology Source Type: research
Long term low temperature storage of living tissue is an active area of research. Cryoprotectant perfusion allows tissues to vitrify on cooling, minimizing ice crystal formation and thus preserving the small scale structure that is vital to tissue function. The challenge of cooling to vitrification is largely the challenge of obtaining good perfusion of cryoprotectant throughout the tissue, something that is much less of an issue for an isolated organ or tissue sample than it is for an entire animal or human. The more significant challenges are those related to the goal of warming vitrified tissue while retaining full func...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
We present a case of SJS in a patient with adult polycystic kidney disease (ADPKD) and color vision deficiency. The patient presented to our clinic for evaluation for progressively worsening dyspnea and cough. His imaging revealed a hypoplastic left lung with fibrosis, cystic airway disease, and a small left pulmonary artery. His spirometry revealed an obstructive defect. A Ventilation-Perfusion scan (V/Q) showed a significant reduction of ventilation and perfusion to his left lung confirming the diagnosis of SJS. Both conditions - SJS and ADPKD-are not pathologically or genetically related and are very rare. Having both c...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Source Type: research
ObjectiveTo evaluate the diagnostic performance of preoperative contrast-enhanced ultrasound (CEUS) in the detection of extracapsular extension (ECE) and cervical lymph node metastasis (LNM) of papillary thyroid carcinoma (PTC) and the added value of CEUS in the evaluation of PTC invasiveness to conventional ultrasound (US).Materials and MethodsA total of 62 patients were enrolled retrospectively, including 30 patients with invasive PTCs (Group A, ECE or LNM present) and 32 patients with non-invasive PTCs (Group B). All patients underwent US and CEUS examinations before surgery. US and CEUS features of PTCs and lymph nodes...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Basic Res Cardiol. 2022 Jan 13;117(1):1. doi: 10.1007/s00395-022-00909-8.ABSTRACTHeart failure is a clinical syndrome where cardiac output is not sufficient to sustain adequate perfusion and normal bodily functions, initially during exercise and in more severe forms also at rest. The two most frequent forms are heart failure of ischemic origin and of non-ischemic origin. In heart failure of ischemic origin, reduced coronary blood flow is causal to cardiac contractile dysfunction, and this is true for stunned and hibernating myocardium, coronary microembolization, myocardial infarction and post-infarct remodeling, possibly ...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
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