Extracellular Vesicles in Kidney Transplantation: A State of the Art Review

Kidney transplantation is the optimal treatment for patients with end-stage renal disease however, early detection and timely treatment of graft injury remain a challenge. Precise and non-invasive techniques of graft assessment and innovative therapeutics are required to improve kidney transplantation outcomes. Extracellular vesicles (EVs) are lipid bilayer-delimited particles with unique biosignatures and immunomodulatory potential, functioning as intermediaries of cell signalling. Promising evidence exists for the potential of EVs to develop precision diagnostics of graft dysfunction, and prognostic biomarkers for clinician decision making.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: review Source Type: research