New ‘Heavily Mutated’ B.1.1.529 Covid-19 Coronavirus Variant Spreading In South Africa

The World Health Organization (WHO) will meet tomorrow to determine if the B.1.1.529 SARS-CoV-2 variant should be considered a variant of interest or concern.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Tags: Healthcare /healthcare Innovation /innovation Science /science business pharma Source Type: news

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ConclusionVariations of pH occurred in the majority (79.7%) of patients admitted with COVID-19. The patients experienced all the type of acid –base disorders, notably metabolic and respiratory alkalosis were the most common alterations in this group of patients.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
Biochem Biophys Res Commun. 2022 Jan 15;593:52-56. doi: 10.1016/j.bbrc.2022.01.038. Online ahead of print.ABSTRACTCOVID-19, the respiratory infection caused by the novel coronavirus SARS-CoV-2, presents a clinical picture consistent with the dysregulation of many of the pathways mediated by the metalloprotease ADAM17. ADAM17 is a sheddase that plays a key role in the modulation of ACE2, the receptor which also functions as the point of attachment leading to cell entry by the virus. This work investigates the possibility that ADAM17 dysregulation and attachment of the SARS-CoV-2 virion to the ACE2 receptor are linked events...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Source Type: research
This study is the first to provide a basis for the higher infectivity of the new SARS-CoV-2 variants and provides a strong impetus for the development of novel drugs against them.PMID:35063482 | DOI:10.1016/j.ijbiomac.2022.01.059
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Source Type: research
Conclusions. SARS-CoV-2 infection in CLL patients is associated with poor outcome regardless of administered CLL-directed treatment.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
This report describes COVID-19 vaccine effectiveness time frames among people who received their first and second doses of the vaccine series, and effectiveness of third vaccine doses during both Delta- and Omicron-predominant periods.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: Adult Health Coronavirus [CoV] Hospitalization rates MMWR Morbidity & Mortality Weekly Report SARS (Severe acute respiratory syndrome) Vaccination Vaccines COVID-19 Source Type: news
Condition:   COVID-19 Intervention:   Diagnostic Test: real time PCR Sponsor:   Sohag University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This report describes COVID-19 incidence rate ratios for unvaccinated versus fully vaccinated persons with and without booster vaccine doses during the emergence of the Omicron variant.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: Adult Health Coronavirus [CoV] MMWR Morbidity & Mortality Weekly Report SARS (Severe acute respiratory syndrome) Vaccination Vaccines Death Rates COVID-19 Source Type: news
We present the examples of structure-based design of Pfizer's novel anti-SARS-CoV-2 drug PF-07321332 (Paxlovid), Merck's nucleotide inhibitor molnupiravir (Lagevrio), and VV116, an oral drug candidate for COVID-19. These examples highlight the importance of structure in drug discovery to combat COVID-19. We also discussed the recent variants of Omicron and its implication in immunity escape from existing vaccines and antibody therapies.PMID:35058587 | DOI:10.1038/s41401-021-00851-w
Source: Acta Pharmacologica Sinica - Category: Drugs & Pharmacology Authors: Source Type: research
In this study, we collected 3,508 nasopharyngeal swab samples from 3,249 patients who visited the Yamanashi Central Hospital in Japan from March 1, 2020 to February 28, 2021. We performed multiplex polymerase chain reaction (PCR) using the FilmArray Respiratory Panel and singleplex quantitative reverse transcription PCR targeting SARS-CoV-2 to detect respiratory disease-associated pathogens. At least one pathogen was detected in 246 (7.0%) of the 3,508 samples. Eleven types of pathogens were detected in the samples collected from March-May 2020, during which non-pharmaceutical interventions were not well implemented. In co...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
Int J Mol Med. 2022 Mar;49(3):33. doi: 10.3892/ijmm.2022.5088. Epub 2022 Jan 21.ABSTRACTThe pandemic caused by the severe acute respiratory syndrome coronavirus (SARS‑CoV‑2), responsible for coronavirus disease 2019 (COVID‑19) has posed a major challenge for global health. In order to successfully combat SARS‑CoV‑2, the development of effective COVID‑19 vaccines is crucial. In this context, recent studies have highlighted a high COVID‑19 mortality rate in patients affected by β‑thalassemia, probably due to their co‑existent immune deficiencies. In addition to a role in the severity of SARS‑CoV‑2 ...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
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