Dennettia tripetala preserves hepatic and renal tissue structure and function

This study was therefore designed to test the ability ofDennettia tripetala (D. tripetala) to prevent severe liver and kidney damage, caused by repeated exposures to CCl4. Rats were force-fed daily withD. tripetala extracts for 21  days, and from day 18 to 21, CCl4 was additionally administered. Positive and negative controls  were included. At the end of the experiment, the animals were sacrificed and subjected to biochemical and histopathological examinations. CCl4 caused elevations in serum activities of liver enzymes, as well as total protein and globulin concentration, while the albumin concentration dropped drastically. In the liver, the concentration of lipids increased, with a concomitant decrease in the blood. The concentration of urea and creatinine in the blood also increased, the activity of antioxidant enzymes in the liver and kidneys dropped, and the concentration of malondialdehyde in these organs increased significantly. There were also histopathological changes in the liver and kidneys, andD. tripetala significantly prevented these hepatorenal injuries. Taken together, the results show thatD. tripetala can prevent the liver and kidneys from severe damage triggered by repeated exposures to CCl4.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research