Diagnostic Value of VDR in Bone Metastasis and Prognosis of Patients with Breast Cancer and Expression Correlation between VDR and Hr

This study aimed to explore the expression of VDR/Hr in breast cancer, and the correlation between VDR/Hr and prognosis, bone metastasis, and metastasis-related prognosis. Methods: The expression of VDR and Hr was performed on 119 breast cancer tissues and corresponding normal breast tissue from each of the breast cancer samples by Immunohistochemistry (IHC) staining, and the databases were supplemented as well. Results: The expression of VDR protein was significantly decreased in breast cancer patients (p 0.05) databases showed VDR mRNA expression tended to be higher in tumor tissues. Hr protein was expressed at low level within breast cancer specimens (p 0.05). The protein levels of VDR and Hr were positively correlated (p> 0.05), while the mRNA levels suggested a closely relationship in the GEPIA (p 0.05). Whereas, VDR protein and mRNA low expression had markedly shorter OS and RFS (both p
Source: Oncology Research and Treatment - Category: Cancer & Oncology Source Type: research