P16INK4a/ki67 immunocytochemistry in improving the predictive value for high grade cervical intraepithelial ( & #8805;CIN2) neoplasia in pap smear

Conclusion: Because high-risk HPV test has a high sensitivity and NPV, whereas P16/Ki-67 dual immunocytochemistry (≥10 positive cells) has a high specificity and PPV, the latter can be recommended as an ancillary test in hr-HPV-positive women to reduce the number of women going for colposcopy and biopsies.

Source: Journal of Cytology - November 22, 2021 Category: Cytology Authors: G Vinoth Kumar Anne Jennifer Prabhu Ajit Sebastian Raghavendran Priya Abraham Abraham Peedicayil Source Type: research