Cortical consequences of HIV-1 Tat exposure in rats are enhanced by chronic cocaine.

Cortical consequences of HIV-1 Tat exposure in rats are enhanced by chronic cocaine.
Curr HIV Res. 2015 Mar 11;
Authors: Wayman WN, Chen L, Persons AL, Napier TC
Abstract
The life span of individuals that are sero-positive for human immunodeficiency virus (HIV) has greatly improved; however, complications involving the central nervous system (CNS) remain a concern. While HIV does not directly infect neurons, the proteins produced by the virus, including HIV transactivator of transcription (Tat), are released from infected glia; these proteins can be neurotoxic. This neurotoxicity is thought to mediate the pathology underlying HIV-associated neurological impairments. Cocaine abuse is common among HIV infected individuals, and this abuse augments HIV-associated neurological deficits. The brain regions and pathophysiological mechanisms that are dysregulated by both chronic cocaine and Tat are the focus of the current review.
PMID: 25760043 [PubMed - as supplied by publisher]

Source: Current HIV Research - March 11, 2015 Category: Infectious Diseases Authors: Wayman WN, Chen L, Persons AL, Napier TC Tags: Curr HIV Res Source Type: research