A Possible Mechanism of Action of 17 α-Hydroxyprogesterone Caproate: Enhanced IL-10 Production
Conclusion In women receiving 17-OHPC for PTB prevention, we demonstrate a relationship between plasma 17-OHPC and LPS-stimulated IL-10 production by circulating leukocytes. We also demonstrate that, in vitro, 17-OHPC treatment affects IL-10 production by LPS-stimulated macrophages. Collectively, these findings support an immunomodulatory mechanism of action of 17-OHPC in the prevention of recurrent PTB.
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Source: American Journal of Perinatology - Category: Perinatology & Neonatology Authors: Megli, Christina J. Hauspurg, Alisse Venkataramanan, Raman Caritis, Steve N. Tags: Original Article Source Type: research