Silent information regulator 1 ameliorates oxidative stress injury via PGC-1 α/PPARγ-Nrf2 pathway after ischemic stroke in rat

CONCLUSION: Overall, our data indicated that SIRT1 directly mediated the PGC-1α/PPARγ pathway in response to focal cerebral ischemia/reperfusion-induced neurological deficit, providing insights into the treatment of focal cerebral ischemia/reperfusion injury.PMID:34774993 | DOI:10.1016/j.brainresbull.2021.11.001
Source: Brain Research Bulletin - Category: Neurology Authors: Source Type: research