EZH2-mediated suppression of CLDN1 leads to barrier dysfunction in PPI-refractory gastroesophageal reflux disease

PPI-refractory gastroesophageal reflux disease (RGERD) is characterized as the existence of reflux symptoms resistant to optimized PPI treatment. Alleviated mucosal integrity has been regarded as one of the mechanisms of RGERD.

Source: Digestive and Liver Disease - November 14, 2021 Category: Gastroenterology Authors: Teng Ma, Jie Gu, Ye Zhao, Su Li, Di Ge, Duowu Zou Tags: Alimentary Tract Source Type: research