Fibrinolytic Impairment and Mortality in Pediatric Septic Shock: A Single-Center Prospective Observational Study*

This study aimed to identify the association between impaired fibrinolysis and mortality in pediatric septic shock. DESIGN: A prospective, observational study conducted between August 2019 and August 2020. SETTING: PICU at a pediatric tertiary hospital in Hanoi, Vietnam. PATIENTS: Fifty-six pediatric patients who met septic shock criteria were enrolled. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Conventional coagulation tests and rotational thromboelastometry were performed at diagnosis. The fibrinolytic activity on extrinsic pathway thromboelastometry was negatively correlated with the Vasoactive-Inotropic Score at 24 hours post-PICU admission, peak lactate level during the first 24 hours, Pediatric Logistic Organ Dysfunction-2 score, and Pediatric Risk of Mortality-III score (all p
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Clinical Investigations Source Type: research