Fibrinolytic Impairment and Mortality in Pediatric Septic Shock: A Single-Center Prospective Observational Study*

This study aimed to identify the association between impaired fibrinolysis and mortality in pediatric septic shock. DESIGN: A prospective, observational study conducted between August 2019 and August 2020. SETTING: PICU at a pediatric tertiary hospital in Hanoi, Vietnam. PATIENTS: Fifty-six pediatric patients who met septic shock criteria were enrolled. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Conventional coagulation tests and rotational thromboelastometry were performed at diagnosis. The fibrinolytic activity on extrinsic pathway thromboelastometry was negatively correlated with the Vasoactive-Inotropic Score at 24 hours post-PICU admission, peak lactate level during the first 24 hours, Pediatric Logistic Organ Dysfunction-2 score, and Pediatric Risk of Mortality-III score (all p
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Clinical Investigations Source Type: research

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CONCLUSIONS: This meta-analysis highlights the main clinical symptoms used for the diagnosis of MIS-C, the differences between MIS-C and KD, and the severity of the inflammatory process and urgency for hospital care.PMID:34863701 | DOI:10.1016/j.jped.2021.08.006
Source: Jornal de Pediatria - Category: Pediatrics Authors: Source Type: research
AbstractThe accuracy of pulse pressure variation (PPV) to predict fluid responsiveness using pressure-controlled (PC) instead of volume-controlled modes is under debate. To specifically address this issue, we designed a study to evaluate the accuracy of PPV to predict fluid responsiveness in severe septic patients who were mechanically ventilated with biphasic positive airway pressure (BIPAP) PC-ventilation mode. 45 patients with sepsis or septic shock and who were mechanically ventilated with BIPAP mode and a target tidal volume of 7 –8 ml/kg were included. PPV was automatically assessed at baseline and after a...
Source: Journal of Clinical Monitoring and Computing - Category: Information Technology Source Type: research
Condition:   Septic Shock Interventions:   Drug: Ivabradine 5mg Tab;   Drug: Placebo Sponsor:   Cairo University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Ann Med. 2021 Dec;53(1):2268-2277. doi: 10.1080/07853890.2021.2009125.ABSTRACTOBJECTIVES: Lactate/albumin (L/A) ratio is a biomarker in sepsis that has been shown to outperform lactate. This prospective study aims to validate the superior prognostic value of the L/A ratio to lactate in sepsis and septic shock.METHODS: Prospective cohort conducted from September 2018 till February 2021 on adult patients presenting to the Emergency Department (ED) at a tertiary care centre with sepsis or septic shock. The primary outcome was the prognostic value of the L/A ratio compared to lactate with regards to mortality.RESULTS: A total ...
Source: Annals of Medicine - Category: Internal Medicine Authors: Source Type: research
Excessive inflammation drives the progression from sepsis to septic shock. Macrophage migration inhibitory factor (MIF) is of interest because MIF promoter polymorphisms predict mortality in different infections, and anti-MIF antibody improves survival in experimental models when administered 8 hours after infectious insult. The recent description of a second MIF superfamily member, D-dopachrome tautomerase (D-DT/MIF-2), prompted closer investigation of MIF-dependent responses. We subjected Mif–/– and Mif-2–/– mice to polymicrobial sepsis and observed a survival benefit with Mif but not Mif-2 defici...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
CONCLUSIONS: Bacterial etiology of necrotizing pneumonia in children varied with the presence or absence of a complex chronic condition. Bacterial isolation is associated with increased invasive procedures and complications. The mortality rate is higher in children with complex chronic conditions. This study provides national data on necrotizing pneumonia among hospitalized children.
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Online Brief Reports Source Type: research
Annals of the American Thoracic Society,Volume 18, Issue 12, Page 2049-2057, December 2021.
Source: Annals of the American Thoracic Society - Category: Respiratory Medicine Authors: Source Type: research
CONCLUSION Adenosine, lidocaine, and magnesium may prove beneficial in mitigating the inflammatory response seen from REBOA-associated IRI as evidenced by physiologic improvements early during resuscitation. Despite this, further refinement should be sought to optimize treatment strategies.
Source: The Journal of Trauma: Injury, Infection, and Critical Care - Category: Orthopaedics Tags: 2021 EAST PODIUM Source Type: research
Conclusion: Anti-ERS and anti-mPTP-opening by the combination of PBA and CsA was beneficial to septic shock. PBA enforced the CsA-associated cardiovascular protection and contributed to the synergetic effect.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conditions:   Septic Shock;   Cytokine Storm Intervention:   Device: HA-330 Disposable Hemoperfusion Cartridge (Jafron, China) Sponsors:   Mahidol University;   Faculty of Medicine Siriraj Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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