Pirfenidone Attenuates Renal Tubulointerstitial Fibrosis through Inhibiting miR-21

Conclusions: PFD improves TIF by downregulating the expression of miR-21, then elevating Smad7, and finally inhibiting the activation of the TGF- β1/Smad3 signaling pathway in UUO rats.Nephron
Source: Nephron - Category: Urology & Nephrology Source Type: research