Clinical outcomes and complications of fluid-filled scleral lens devices for the management of limbal stem cell deficiency

Corneal epithelial cells renewal and corneal transparency rely on the normal function of corneal epithelial stem cells located in the limbus, i.e. the junction between the cornea and the sclera [1]. These limbal stem cells (LSCs) are regulated by their surrounding microenvironment, the LSCs niche [2 –4]. Dysfunction or destruction of the niche and/or of the LSCs from a variety of etiologies results in limbal stem cell deficiency (LSCD), a disease that can lead to corneal blindness [5]. Medical management of LSCD entails a stepwise approach to improve the ocular surface, including the treatmen t of any ocular surface comorbidities impairing the function of LSCs [6].
Source: Contact Lens and Anterior Eye - Category: Opthalmology Authors: Source Type: research