Notice of Intent to Publish a Funding Opportunity Announcement for Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Cerebroprotection - Interventions from Small Businesses (U44 CT Not Allowed)

Notice NOT-NS-22-037 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding

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HIGH blood pressure, also known as hypertension, can lead to serious health problems including heart attacks and strokes. Dubbed as a "silent killer" because of its rarely noticeable symptoms, the only way to find out for sure is to have your levels checked. But there's one sign found on your face which could be signalling the condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
STROKES can be deadly, but knowing the warning signs and receiving them is one way you can reduce your risk of long-term effects or death. Did you know the symptoms are different for men and women?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Most of the work aimed at treating aging as a medical condition is focused on stress response upregulation, finding ways to trigger some of the regulatory pathways and mechanisms involved in beneficial cellular reactions to the mild stresses of exercise, reduced calorie intake, hypoxia, heat, cold, and so forth. Improved cell behavior leads to improved tissue function, which in turn slows the progression of degenerative aging. Many of these pathways converge on autophagy, and evidence from the study of calorie restriction suggests that improved autophagy is the largest contributing factor. Autophagy is the name give...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
THE BAD reputation of bad cholesterol is mainly attributable to its clogging effect on the arteries. As the arteries narrow, blood carrying key nutrients struggles to reach the vital organs. Unfortunately, high cholesterol does not produce symptoms. Further down the line, however, changes in the face could be a warning that a stroke might be imminent.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Anasthesiol Intensivmed Notfallmed Schmerzther. 2021 Dec;56(11-12):746-759. doi: 10.1055/a-1330-5239. Epub 2021 Nov 24.ABSTRACTStroke is one of the most common neurological emergencies and requires rapid detection and treatment (time is brain). There is still insufficient knowledge about stroke warning signs. It is therefore of crucial importance that trained personnel in the preclinical setting recognize the relevant warning symptoms and collect the necessary information to quickly refer the patient to the appropriate additional care structure. For this purpose, training of the emergency medical services (EMS) and the cor...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - Category: Intensive Care Authors: Source Type: research
This study aims to investigate the association between seven urinary PAH concentrations (1-hydroxynaphthalene, 2-hydroxynaphthalene, 3-hydroxyfluorene 2-hydroxyfluorene, 1-hydroxyphenanthrene, 1-hydroxypyrene, and 2 &3-hydroxyphenanthrene) and CKD in the US adult population. A cross-sectional analysis using the 2015-2016 National Health and Nutrition Examination Survey (NHANES) dataset was conducted. CKD was defined with estimated glomerular filtration rate (eGFR) and albumin to creatinine ratio (ACR). Participants with an eGFR 30 mg/gm were considered to have CKD. A specialized complex survey design analysis package u...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Source Type: research
Conclusions: Modeled EMS prehospital triage of ELVO patients ’ results in shorter MT times without a change in thrombolysis times. As triage tools increase in sensitivity and specificity, EMS triage protocols stand to improve patient outcomes.Cerebrovasc Dis Extra 2021;11:137 –144
Source: Cerebrovascular Diseases Extra - Category: Neurology Source Type: research
This study aimed to establish the effectiveness and safety of apixaban and rivaroxaban in patients with NVAF and BMI ≥50 kg/m2.MethodsA single health-system, retrospective cohort study evaluated the effectiveness and safety of apixaban and rivaroxaban initiated in adult patients ( ≥18 years of age) with BMI ≥50 kg/m2 and NVAF. Outcomes of ischemic stroke, systemic embolic events, and bleeding were compared to a cohort of patients with BMI 18 to 30 kg/m2.ResultsAfter 1,619 patient-years ’ worth of follow up in 595 patients, the primary endpoint of incidence of ischemic stroke was numerically similar in both g...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Despite projections of stroke being a leading cause of mortality in Africa, reliable estimates of stroke burden on the continent using rigorous methods are not available. We aimed to implement a mobile-Health community-based interactive Stroke Information and Surveillance System to sustainably measure stroke burden and improve stroke health literacy and outcomes in urban and rural sites in Nigeria. African Rigorous Innovative Stroke Epidemiological Surveillance (ARISES) is an observational cohort study, which will be conducted in urban (Ibadan North LGA Ward 3) and rural (Ibarapa Central LGA) sites with a combined base pop...
Source: Neuroepidemiology - Category: Epidemiology Source Type: research
This case occurred in a 33-year-old man who has been smoking for 19 years. He had a pattern of consuming 14 cigarettes per day with 30 mg of nicotine intake and high tar levels. The level of tolerance for consumption of nicotine and tar per day is 10 to 15 mg. High cigarette consumption correlates with high nicotine consumption as well. Excessive nicotine consumption over a long period can lead to lung cancer, stroke, heart disease, chronic obstructive pulmonary disease, and psychological disorders.
Source: Addictive Disorders and Their Treatment - Category: Addiction Tags: Case Reports Source Type: research
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