Deregulation of circ_003912 contributes to pathogenesis of erosive oral lichen planus by via sponging microRNA-123, -647 and -31 and upregulating FOXP3

CONCLUSION: In this study, we investigated the molecular mechanisms underlying the pathogenesis of EOLP which involved the functioning of circ_003912. We first demonstrated that circ_003912 was up-regulated in CD4+ T-cells of the EOLP group. And miRNAs including miR-1231, miR-31 and miR-647 were sponged by circ_003912 and down-regulated in CD4+ T cells of the EOLP group, which subsequently up-regulated the expression of FOXP3 and miR-146a, and resulted in the inhibition of NF-kB.PMID:34670484 | DOI:10.1186/s10020-021-00382-4

Source: Molecular Medicine - October 21, 2021 Category: Molecular Biology Authors: Zhen Huang Fen Liu Wenjuan Wang Shaobo Ouyang Ting Sang Zikun Huang Lan Liao Jun Wu Source Type: research