Osteoskeletal Regenerative Ability of Exosomes Derived From Adipose-derived Stem Cells Upon Inhibition of Transforming Growth Factor- β-signaling

Reconstruction of bone defects represents a major challenge due to its poor self-regenerating capabilities. Mesenchymal stem cells (MSC) have been shown to have pro-osteogenic effects in vitro and in vivo. Recently, there has been a paradigm shift implying the MSC-derived secretome to be the key player in tissue engineering, rather than the differentiation potential of MSCs. MSC-derived microvesicles (MV) have been shown to enhance osteogenic function in vitro and in vivo via transfer of osteogenic miRNAs and proteins.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Transplantation and Tissue Engineering Source Type: research