Venous Thromboembolism for the Practicing Cardiologist

Venous thromboembolism (VTE), encompassing pulmonary embolism (PE) and deep vein thrombosis (DVT), is encountered commonly. Acute PE may present as a high-risk cardiovascular emergency, and acute DVT can cause acute and chronic vascular complications. The goal of this review is to ensure that cardiologists are comfortable managing VTE —including risk stratification, anticoagulation therapy, and familiarity with primary reperfusion therapy. Clinical assessment and determination of degree of right ventricular dysfunction are critical in initial risk stratification of PE and determination of parenteral versus oral anticoagulation therapy. Direct oral anticoagulants have emerged as preferred first-line oral anticoagulation strategy in VTE scenarios.
Source: Cardiology Clinics - Category: Cardiology Authors: Source Type: research

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Endothelial-platelet theory of the development of a systemic inflammatory reaction in COPD on the background of COVID-19 with manifestations of interstitial pneumonitis associated with the Sars-Cov2 virus as a trigger is quite real.Aim: To study the ability of erythrocytes (ER) to deform (IDE) in COPD on the background of coronavirus infection and pathogenetically justify the ways of correction.Material and methods: There were randomized clinical groups: 1st group - patients with COPD and COVID-19 (18 people; men - 11, women - 7); 2nd group - patients with COPD in the acute phase (21 people; men - 12, women - 9).Results an...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Airway cell biology and immunopathology Source Type: research
Conclusion: PAVMs can have life-threatening complications. Surgery may be considered the first choice when embolization is not available or has not been successful, when the desease is anatomically limited or cases where the PAVM diagnosis cannot be established.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Thoracic surgery Source Type: research
Rationale: The recent guideline on acute pulmonary embolism from the European Society of Cardiology indicates possible long-term sequelae such as dyspnoea and chronic thromboembolic pulmonary hypertension after a pulmonary embolism event, however, lung function or asthma risk have not been previously evaluated in the general population.Methods: We tested whether individuals with current or previous venous thromboembolism have reduced lung function, or greater risk of dyspnoea or asthma using data from 21,205 individuals from the Danish General Suburban Population Study.Results: Individuals who reported pulmonary embol...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary embolism Source Type: research
Background: Due to repeated exacerbations a large group of patients with chronic obstructive pulmonary disease (COPD) are often exposed to oral corticosteroids (OCS). Corticosteroids may be thrombogenic. We evaluated the risk of venous thromboembolia and death in patients with acute exacerbation of COPD (AECOPD) according to two different dosing regimens.Method: This was a nationwide observational cohort study of outpatients with COPD with a 6 month follow up time. It was based on a linked administrative registry data between January 1st 2010 and 28th February 2018. In total 30.473 patients treated with either short course...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary embolism Source Type: research
Background: Septic pulmonary embolism (SPE) in children is a rare disease. There is scarce data regarding the clinical and laboratory manifestation of SPE compared with non-septic pulmonary embolism (ns-PE). Furthermore, there are no specific guidelines for the management and the follow up of SPE in pediatric patients.Aim: To compare the clinical course and outcome of children with SPE and ns-PE.Methods: A retrospective, cohort study of hospitalized children
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary embolism Source Type: research
Discussion: This review highlights the importance of screening of lung disease associated with RA, in order to optimize the follow-up of these pts.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ILD / DPLD of known origin Source Type: research
Conclusion: Since all of these patients presented to our clinic as presumptive COVID patients, our series highlights the need of careful evaluation of patients with happy hypoxia for causes other than COVID-19.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical problems Source Type: research
Conclusions: The frequency of occurrence of the heterozygous genotype G / A for FV-Leiden and PRT G20210A in the COPD patients with thrombotic events significantly exceeded the frequency in the group COPD patients with out trombosis, which may indicate the role of this genes in the development of thrombophilic conditions in COPD.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Molecular pathology and functional genomics Source Type: research
Given the pathophysiology of coronavirus disease 19 (COVID-19), persistent pulmonary abnormalities are feared.We conducted a French prospective cohort study in severe COVID-19 patients who had oxygen saturation
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections and bronchiectasis Source Type: research
Conclusions: In Covid-19 patients not receiving high level care, VTE risk is not insignificant. As per known data, D dimers are not useful and clinical risk assessment is useful. Patients tend to be co-morbid, male, with an above average BMI and a lower than average frailty score.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary embolism Source Type: research
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