Aminopeptidases trim Xaa-Pro proteins, initiating their degradation by the Pro/N-degron pathway [Biochemistry]

N-degron pathways are proteolytic systems that recognize proteins bearing N-terminal (Nt) degradation signals (degrons) called N-degrons. Our previous work identified Gid4 as a recognition component (N-recognin) of the Saccharomyces cerevisiae proteolytic system termed the proline (Pro)/N-degron pathway. Gid4 is a subunit of the oligomeric glucose-induced degradation (GID) ubiquitin ligase. Gid4...

Source: Proceedings of the National Academy of Sciences - October 18, 2021 Category: Science Authors: Shun-Jia Chen, Leehyeon Kim, Hyun Kyu Song, Alexander Varshavsky Tags: Biochemistry Biological Sciences Source Type: research