Analysis of Prognostic Significance of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia

Conclusion This study provides the first analysis of the prognostic role of MCPyV in CLL. MCPyV occurrence seems to be a relatively rare event during the course of CLL. MCPyV is also unlikely to influence the outcome of CLL patients. Micro-Abstract Merkel cell polyomavirus (MCPyV) has been found to be associated with chronic lymphocytic leukemia (CLL). We evaluated its prognostic significance in CLL. MCPyV occurrence seems to be a relatively rare event during the course of CLL. MCPyV is also unlikely to influence the outcome of CLL patients.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research

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CONCLUSIONS: Fusion genes were the most common genetic cause of pediatric PTCs. Fusion gene positive PTCs showed more aggressive behavior than fusion gene negative PTCs. Several novel rearrangements were identified. Fusion genes seem to be a molecular marker number one in pediatric PTC patients. PMID: 32495721 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Conclusion: These cases add to the growing literature which shows that surgery might play an important role in the management of PCNSL with an accessible and single lesion. Five-aminolevulinic acid could also be a useful tool to achieve complete resection and improve prognosis in this group of patients. PMID: 32494397 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Conclusion: Physicians should remain vigilant for the possibility of malignancy in their approach to nasal cavity masses, even in young otherwise healthy patients. Careful review of the immunohistopathology should also be taken, as mixed olfactory tumors such as these are aggressive, rare entities that require multidisciplinary oncologic care. PMID: 32494376 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Publication date: Available online 4 June 2020Source: Pharmacological ResearchAuthor(s): Liyang Jia, Yanan Gao, Yaowu He, John D. Hooper, Pengyuan Yang
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 5 June 2020Source: Journal of Geriatric OncologyAuthor(s): Smith Giri, Madan Raj Aryal, Han Yu, Alyssa Grimshaw, Ranjan Pathak, Scott P. Huntington, Binod Dhakal
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Conclusion Addition of novel drugs to the treatment armamentarium of MM is considerably cost-effective. The evaluations became more frequent, methodological quality has improved in the last decade . PMID: 32496881 [PubMed - as supplied by publisher]
Source: Expert Review of Pharmacoeconomics and Outcomes Research - Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research
Authors: García-Caballero L, Caneiro J, Gándara M, González-Ortega N, Cepeda-Emiliani A, Gude F, Collado M, Beiras A, Gallego R Abstract Merkel cells are neuroendocrine cells associated to a neural sensitive ending and localized primarily in the epidermis, although they are also found in oral mucosa. Sox2 or SRY-box2 is a key transcription factor important in the maintenance of embryonic neural crest stem cell pluripotency. Sox2 has been described in Merkel cells of skin and in Merkel cell carcinomas, but not specifically in oral Merkel cells. The aims of the present study were to analyze the d...
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
microRNA-23B inhibits non-small cell lung cancer proliferation, invasion and migration via downregulation of RUNX2 and inhibition of Wnt/Β-catenin signaling pathway. J Biol Regul Homeost Agents. 2020 Jun 04;34(3): Authors: Wang HX, Wang XY, Fei JW, Li FH, Han J, Qin X Abstract Non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancer cases. MicroRNAs (miRNAs/miRs) have been reported to play significant roles in the progression of human tumors, however, the expression and biological role of miR-23b in NSCLC remains elusive. Underexpression of miR-23b was detected in NSCLC tissues...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Publication date: Available online 4 June 2020Source: Stem Cell ReportsAuthor(s): Baskar Ramdas, Raghuveer Singh Mali, Lakshmi Reddy Palam, Ruchi Pandey, Zhigang Cai, Santhosh Kumar Pasupuleti, Sarah S. Burns, Reuben Kapur
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Conclusion This study provides the first analysis of the prognostic role of MCPyV in CLL. MCPyV occurrence seems to be a relatively rare event during the course of CLL. MCPyV is also unlikely to influence the outcome of CLL patients. Teaser Merkel Cell polyomavirus (MCPyV) has been found to be associated with chronic lymphocytic leukemia (CLL). We evaluated its prognostic significance in CLL. MCPyV occurrence seems to be a relatively rare event during the course of CLL. MCPyV is also unlikely to influence the outcome of CLL patients.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
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