VectorBuilder and Landau enter into strategic partnership to establish world & rsquo;s first primate gene therapy R & amp;D center

Source: The Scientist - Category: Science Tags: The Scientist The Marketplace Source Type: news

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Cancer Gene Therapy, Published online: 01 December 2021; doi:10.1038/s41417-021-00402-9Correction: microRNA-let-7e in serum-derived exosomes inhibits the metastasis of non-small-cell lung cancer in a SUV39H2/LSD1/CDH1-dependent manner
Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research
Rejuvenation Res. 2021 Nov 27. doi: 10.1089/rej.2021.0036. Online ahead of print.ABSTRACTHere presented for the first time, are results showing persistence over a 5+ year period, in a human who had a hormone gene therapy administered to muscle. This GHRH therapy was administered in 2 doses, a year apart, with a mean after the second dose of 195 ng/ml (13X normal, σ=143, σM= 34, max=495, min=53). This level of GHRH therapy appears to be safe for the subject, although there were some adverse events. IGF-1 levels were little affected, nor were GH test results, showing no indications of acromegaly for the hormone h...
Source: Cell Research - Category: Cytology Authors: Source Type: research
J Mol Med (Berl). 2021 Nov 27. doi: 10.1007/s00109-021-02167-y. Online ahead of print.ABSTRACTNeurogenetic diseases are neurological conditions with a genetic cause (s). There are thousands of neurogenetic diseases, and most of them are incurable. The development of bioinformatics and elucidation of the mechanism of pathogenesis have allowed the development of gene therapy approaches, which show great potential in treating neurogenetic diseases. Viral vectors delivery, antisense oligonucleotides, gene editing, RNA interference, and burgeoning viroid delivery technique are promising gene therapy strategies, and commendable ...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
Colloids Surf B Biointerfaces. 2021 Nov 17:112219. doi: 10.1016/j.colsurfb.2021.112219. Online ahead of print.ABSTRACTPolyethylenimine (PEI) has been demonstrated as an efficient DNA delivery vehicle both in vitro and in vivo. There is a consensus that PEI-DNA complexes enter the cells by endocytosis and escape from endosomes by the so-called "proton sponge" effect. However, little is known on how and where the polyplexes are de-complexed for DNA transcription and replication to occur inside the cell nucleus. To better understand this issue, we (i) tracked the cell internalization of PEI upon transfection to huma...
Source: Colloids and Surfaces - Category: Biotechnology Authors: Source Type: research
J Mol Med (Berl). 2021 Nov 27. doi: 10.1007/s00109-021-02167-y. Online ahead of print.ABSTRACTNeurogenetic diseases are neurological conditions with a genetic cause (s). There are thousands of neurogenetic diseases, and most of them are incurable. The development of bioinformatics and elucidation of the mechanism of pathogenesis have allowed the development of gene therapy approaches, which show great potential in treating neurogenetic diseases. Viral vectors delivery, antisense oligonucleotides, gene editing, RNA interference, and burgeoning viroid delivery technique are promising gene therapy strategies, and commendable ...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
The first category included biopharmaceuticals, complex generic drugs, patented drugs or drugs nearing patent expiry, cell-based or gene therapy drugs, orphan drugs, special empty capsules like HPMC, pullulan, enteric etc., complex excipients, and phytopharmaceuticals.
Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news
Conditions:   Hodgkins Lymphoma;   Non Hodgkins Lymphoma Intervention:   Biological: TAA-specific CTLs Sponsors:   Baylor College of Medicine;   Center for Cell and Gene Therapy, Baylor College of Medicine Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
Curr Gene Ther. 2021 Nov 25. doi: 10.2174/1566523221666211126105940. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the sixth globally diagnosed cancer with a poor prognosis. Although the pathological factors of hepatocellular carcinoma are well elucidated, the underlying molecular mechanisms remain unclear. N6-methyladenosine (m6A) is an adenosine methylation occurring at the N6 site, which is the most prevalent modification of eukaryotic mRNA. Recent studies have shown that m6A can regulate gene expression, thus modulating the processes of cell self-renewal, differentiation, and apoptosis. The methyls in...
Source: Current Gene Therapy - Category: Genetics & Stem Cells Authors: Source Type: research
This week's life sciences industry news also includes a Devon company adding a patent tied to its lead new drug candidate.
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
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