Fractional carbon dioxide laser for treating hypertrophic scars: A systematic review of randomised trials

Australas J Dermatol. 2021 Oct 10. doi: 10.1111/ajd.13730. Online ahead of print.ABSTRACTHypertrophic scars present collagen deposition and an abnormal extracellular matrix that cause abnormal shape changes and limit normal movement. Although fractional carbon dioxide (CO2 ) laser therapy has provided promising evidence, the improvement of scarring has not been thoroughly reviewed. A systematic review of prospective randomised trial articles collected from PubMed, MEDLINE, EMBASE, Cochrane and Scopus databases was conducted on 15 March 2020 in accordance with the PRISMA-P statement. Types and duration of fractional carbon dioxide laser used in this study along with the comparative modalities were recorded in this review. Treatment efficacy was assessed as the primary outcome. Adverse events and patient satisfaction were assessed as the secondary outcome. Five prospective randomised studies were included in this study. All studies included showed a consistent result with a conclusion that CO2 fractional laser treatment demonstrated statistically significant improvement for various scar scoring methods. Combination with other modalities may yield better results in some studies with the risk of more severe adverse events. Temporary side effects such as itching or burning sensation, erythema and oedema were present but appeared to be minimal and well tolerated. Overall patients reported significant improvement in quality of life. Some of the studies are uncontrolled with relative...
Source: The Australasian Journal of Dermatology - Category: Dermatology Authors: Source Type: research

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Conclusion: In conclusion, the use of patterned ablative Er:YAG laser with a PS01 handpiece and parameters used in this study comprise an effective tool for treatment of mild to moderate rhinophyma with rapid postoperative recovery compared with conventional surgical procedures and other ablative lasers. PMID: 33335414 [PubMed]
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research
Radiation therapy is an effective cancer treatment; however, significant cutaneous adverse events can occur from the skin ’s exposure to ionizing radiation. Chronic radiation dermatitis (CRD) can be a debilitating, disfiguring, and painful condition. Currently there are limited treatment options for CRD, and no criterion standard of care exists. In our clinical study we examine fibrosis, a manifestation of CRD, which can cause pain, functional impairment and decrease patients’ quality of life. Fractional laser therapy (FLT) has been shown to treat fibrosis associated with hypertrophic scars, leading to tissue repair.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
Authors: Huth L, Marquardt Y, Heise R, Fietkau K, Baron JM, Huth S Abstract Injection of dermal fillers is one of the most frequently performed aesthetic procedures. The aim of the present study was to investigate the biological effects of different stabilized hyaluronan (HA) and poly-l-lactic acid fillers with and without subsequent additional fractional laser co-treatment on skin morphology and gene expression. Intradermal injection resulted in a significant enhancement of epidermal thickness detected by histological analysis. Combining HA fillers with ablative fractional CO2- or Er:YAG laser irradiation enhanced...
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Conclusions: Recovery of dermal and epidermal age related atrophy by picosecond laser-toning and picosecond fractional therapy was histologically confirmed. Picosecond fractional therapy demonstrated superior improvement. PMID: 32904059 [PubMed]
Source: Laser Therapy - Category: Laser Surgery Tags: Laser Ther Source Type: research
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Source: Journal of Cosmetic and Laser Therapy - Category: Laser Surgery Authors: Source Type: research
Conclusion: The gel based on methylsilanetriol developed in this study can be successfully used after all laser treatments, but also those related to skin pricking to accelerate regeneration. PMID: 32056471 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Conclusion: The results of this study establish the safety and effectiveness of combined treatment with a 1927 nm thulium laser and a high-intensity precision RF device. ClinicalTrials.gov Identifier: NCT03409965. J Drugs Dermatol. 2019;18(1):59-64. PMID: 30681798 [PubMed - as supplied by publisher]
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Lasers, Microneedling, and Platelet-Rich Plasma for Skin Rejuvenation and Repair. Facial Plast Surg Clin North Am. 2018 Nov;26(4):455-468 Authors: Badran KW, Nabili V Abstract Skin resurfacing for the purpose of rejuvenation and repair continues to evolve with the development of noninvasive or minimally invasive surgical substitutes. Advances in laser therapy, microneedling, and platelet-rich plasma have reinvigorated research in wound repair and regenerative science. An overall positive clinical response toward the use of platelet-rich plasma as an adjuvant to fractional photothermolysis an...
Source: The Surgical Clinics of North America - Category: Surgery Authors: Tags: Facial Plast Surg Clin North Am Source Type: research
AbstractPurposeA linear surgical scar, when located in the head and neck region, can be a significant cosmetic concern. Laser skin resurfacing with a fractional laser and a pulsed dye laser has been proven to be useful for treating such scars. As alternatives, we used a classic ablative CO2 laser in continuous mode with a 1-mm spot size and a 595-nm Nd:YAG laser. We investigated the effect of the combination of the continuous CO2 laser and 595-nm Nd:YAG laser and compared it to the effect of fractional CO2 laser monotherapy on linear scars.MethodsThis was a retrospective, case-controlled study designed to compare the effic...
Source: Aesthetic Plastic Surgery - Category: Cosmetic Surgery Source Type: research
Skin resurfacing for the purpose of rejuvenation and repair continues to evolve with the development of noninvasive or minimally invasive surgical substitutes. Advances in laser therapy, microneedling, and platelet-rich plasma have reinvigorated research in wound repair and regenerative science. An overall positive clinical response toward the use of platelet-rich plasma as an adjuvant to fractional photothermolysis and percutaneous collagen induction is observed. Its effect on post-treatment adverse symptoms, erythema, edema, crusting, and clinical outcomes in rejuvenation are summarized in this article. The lack of ident...
Source: Facial Plastic Surgery Clinics of North America - Category: Cosmetic Surgery Authors: Source Type: research
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