Quantitative Bioluminescence Tomography-guided Conformal Irradiation for Preclinical Radiation Research

Widely used cone beam computed tomography (CBCT)-guided irradiators in preclinical radiation research are limited to localize soft tissue target because of low imaging contrast. Knowledge of target volume is a fundamental need for radiation therapy (RT). Without such information to guide radiation, normal tissue can be overirradiated, introducing experimental uncertainties. This led us to develop high-contrast quantitative bioluminescence tomography (QBLT) for guidance. The use of a 3-dimensional bioluminescence signal, related to cell viability, for preclinical radiation research is one step toward biology-guided RT.

Source: International Journal of Radiation Oncology * Biology * Physics - August 16, 2021 Category: Radiology Authors: Xiangkun Xu, Zijian Deng, Hamid Dehghani, Iulian Iordachita, Michael Lim, John W. Wong, Ken Kang-Hsin Wang Tags: Physics Contribution Source Type: research