Young woman, 25, reveals the terrifying moment she was diagnosed with skin cancer

A young woman who has been battling with an incurable autoimmune disease since the age of 17 has spoken of the terrifying moment she was diagnosed with skin cancer at 25.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Cancer Res. 2021 Oct 12:canres.1148.2021. doi: 10.1158/0008-5472.CAN-21-1148. Online ahead of print.ABSTRACTThe relationship between cancer and autoimmunity is complex. However, the incidence of solid tumors such as melanoma has increased significantly among patients with previous or newly diagnosed systemic autoimmune disease (AID). At the same time, immune checkpoint blockade (ICB) therapy of cancer induces de novo autoinflammation and exacerbates underlying AID, even without evident anti-tumor responses. Recently, systemic lupus erythematosus (SLE) activity was found to drive myeloid-derived suppressor cell (MDSC) forma...
Source: Cell Research - Category: Cytology Authors: Source Type: research
The objective of this study was to evaluate the safety and efficacy of immunotherapy in patients with cancer and preexisting ADs. A retrospective, single-center study of patients with cancer initiated on immune checkpoint inhibitors between 2012 and 2019 was conducted. The primary outcome was the development of immune-related adverse events (irAEs) with respect to the presence of AD at baseline. Associations were assessed using Kaplan-Meier curves, bivariate and multivariable analyses. Of the 417 patients included in this study, 63 patients (15%) had preexisting ADs. A total of 218 patients (53%) developed at least 1 irAE....
Source: Journal of Immunotherapy - Category: Allergy & Immunology Tags: Clinical Studies Source Type: research
J Immunol. 2021 Sep 24:ji2001261. doi: 10.4049/jimmunol.2001261. Online ahead of print.ABSTRACTSystemic suppression of adaptive immune responses is a major way in which UV radiation contributes to skin cancer development. Immune suppression is also likely to explain how UV protects from some autoimmune diseases, such as multiple sclerosis. However, the mechanisms underlying UV-mediated systemic immune suppression are not well understood. Exposure of C57BL/6 mice to doses of UV known to suppress systemic autoimmunity led to the accumulation of cells within the skin-draining lymph nodes and away from non-skin-draining lymph ...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Source Type: research
CONCLUSIONS: In this study, we introduce activin-A as a novel immunomodulatory factor in the lung tumor microenvironment, which bestows exhausted CD4+ T cells with effector properties.PMID:34548096 | PMC:PMC8454162 | DOI:10.1186/s13046-021-02092-5
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
ui Li Animal studies and a few clinical studies have reported mixed findings on the association between antibiotics and cancer incidence. Antibiotics may inhibit tumor cell growth, but could also alter the gut-microbiome-modulated immune system and increase the risk of cancer. Studies that assess how antibiotics affect the progression of cancer are limited. We evaluated the association between broad-spectrum antibiotic use and melanoma progression. We conducted a retrospective cohort study using IQVIA PharMetrics® Plus data (2008–2018). We identified patients with malignant melanoma who underwent wide local e...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
In this study, we used the UK Biobank (n = 440,185) to resolve previous ambiguities in the relationship between serum IGF-1 levels and clinical disease. We examined prospective associations of serum IGF-1 with mortality, dementia, vascular disease, diabetes, osteoporosis, and cancer, finding two generalized patterns. First, IGF-1 interacts with age to modify risk in a manner consistent with antagonistic pleiotropy; younger individuals with high IGF-1 are protected from disease, while older individuals with high IGF-1 are at increased risk for incident disease or death. Second, the association between IGF-1 and risk ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionWe identified novel predictors of rheum-irAEs that included melanoma, genitourinary cancer, pre-existing autoimmune disease, combination ICI, and glucocorticoid use. The proportion of cancer patients experiencing rheum-irAEs may be even higher than we report since we used stringent criteria to identify cases. These findings may identify cancer patients at risk of developing rheum-irAEs andde novo inflammatory arthritis and inform pathogenesis.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: FULL LENGTH Source Type: research
Background: Psoriasis is a chronic, autoimmune dermatologic disease that often requires systemic treatment. Of the immune regulating therapies, methotrexate (MTX) is a commonly used systemic therapy. Both MTX and psoriasis are associated with an increased risk of developing nonmelanoma skin cancers (NMSCs). Currently, the risk associated with combining these factors is not well quantified.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
Conclusions: Patients with a pAID face a significantly higher risk of irAEs. Further research examining the clinical impact of these events on the patients’ oncological outcome and quality of life is urgently needed given our findings of significantly worse rates of adverse events.
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Original Articles: Cutaneous Source Type: research
Adv Drug Deliv Rev. 2021 Jun 17:113833. doi: 10.1016/j.addr.2021.113833. Online ahead of print.ABSTRACTImaging of the lymphatic vasculature has gained great attention in various fields, not only because the traditional role of lymphatic vessels as a draining system in the body, but also for their implication in autoimmune diseases, organ transplant, inflammation and cancer. Thus, neolymphangiogenesis, or the generation of new lymphatics is typically an early event in the development of multiple tumor types, particularly in aggressive ones such as malignant melanoma. Still, the understanding of how lymphatic endothelial cel...
Source: Advanced Drug Delivery Reviews - Category: Drugs & Pharmacology Authors: Source Type: research
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