Effect of donor NKG2D polymorphism on relapse after haploidentical transplantation with post-transplant cyclophosphamide

NKG2D is a transmembrane protein belonging to the C-type lectin-like receptor family, which is encoded by KLRK1 in chromosome 12.[1] It is expressed as a homodimer on natural killer (NK) cells, CD8+ T cells, γδ T cells, most iNKT cells, some CD4+ T cells and innate lymphoid cells.[1-3] It works as an activating receptor in NK cells and a co-stimulatory receptor in CD8+ T cells, iNKT cells and in some cases in γδ T cells.[4-6] NKG2D ligands, including MHC class I chain-related protein A/B (MICA and M ICB) and UL-16 binding protein (ULBP) 1–6, are almost absent in normal cells, although they are up-regulated by cell stress events including cellular transformation and microbial infections, e.g.

Source: Biology of Blood and Marrow Transplantation - September 30, 2021 Category: Hematology Authors: Kentaro Ido, Hideo Koh, Asao Hirose, Toshiyuki Seto, Yosuke Makuuchi, Masatomo Kuno, Teruhito Takakuwa, Hiroshi Okamura, Satoru Nanno, Mika Nakamae, Mitsutaka Nishimoto, Yasuhiro Nakashima, Masayuki Hino, Hirohisa Nakamae Source Type: research